CODIS CORE STR LOCI 概况

一、13 CODIS Core STR Loci

2000年,FBI公布了13对CODIS (Combined DNA Index System)Core STR Loci,如图1:

13 FBI CODIS Core STR Loci

STR位点信息:

Loci Name Gene Name Chromosomal Location Primer Primer # Size Range Repeat Structure Mutation Rate
TPOX TPO 2p25.3 GCACAGAACAGGCACTTAGG CGCTCAAACGTGAGGTTG #5 254-302 [AATG]n 0.01%
D3S1358 LARS2 3p21.31 ACTGCAGTCCAATCTGGGT ATGAAATCAACAGAGGCTTGC #3 99-147 TCTA[TCTG]n[TCTA]n 0.12%
FGA 4q28 GGCTGCAGGGCATAACATTA ATTCTATGACTTTGCGCTTCAGGA #3 308-464 [TTTC]3TTTTTTCT[CTTT]nCTCC[TTCC]2 0.28%
CSF1PO CSF1R 5q33.1 AACCTGAGTCTGCCAAGGACTAGC TTCCACACACCACTGGCCATCTTC #1 287-331 [AGAT]n 0.16%
D5S818 5q23.2 GGGTGATTTTCCTCTTTGGT TGATTCCAATCATAGCCACA #2 129-177 [AGAT]n 0.11%
D7S820 7q21.11 ATGTTGGTCAGGCTGACTATG GATTCCACATTTATCCTCATTGAC #1 211-251 [GATA]n 0.10%
D8S1179 8q24.13 ATTGCAACTTATATGTATTTTTGTATTTCATG ACCAAATTGTGTTCATGAGTATAGTTTC #3 203-255 [TCTA]n[TCTG]n[TCTA]n 0.14%
TH01 TH 11p15.5 GTGGGCTGAAAAGCTCCCGATTAT ATTCAAAGGGTATCTGGGCTCTGG #1 171-215 [AATG]nATG[AATG]n 0.01%
VWA VWF 12p13.31 GCCCTAGTGGATGATAAGAATAATCAGTATGTG GGACAGATGATAAATACATAGGATGGATGG #2 123-183 [TCTA][TCTG]n[TCTA]n[TCCA][TCTA] 0.17%
D13S317 13q31.1 ATTACAGAAGTCTGGGATGTGGAGGA GGCAGCCCAAAAAGACAGA #1 157-205 [TATC]n[AATC]n 0.14%
D16S539 16q24.1 GGGGGTCTAAGAGCTTGTAAAAAG GTTTGTGTGTGCATCTGTAAGCATGTATC #1 260-308 [GATA]n 0.11%
D18S51 18q21.33 TTCTTGAGCCCAGAAGGTTA ATTCTACCAGCAACAACACAAATAAAC #3 286-373 [AGAA]n(AAAGAGAGAG) 0.22%
D21S11 21q21.1 ATATGTGAGTCAATTCCCCAAG TGTATTAGTCAATGTTCTCCAGAGAC #4 155-273 [TCTA]n[TCTG]n[TCTA]n[TA][TCTA]n[TCA][TCTA]n[TCCATA][TCTA]n 0.19%
AMELX X CCCTGGGCTCTGTAAAGAA ATCAGAGCTTAAACTGGGAAGCTG #1 106 -
AMELY Y CCCTGGGCTCTGTAAAGAA ATCAGAGCTTAAACTGGGAAGCTG #1 112 -

二、Additional 7 STR loci

从2017年1月1日起,对于上传至National DNA Index System (NDIS)的数据,FBI要求增加7个STR位点,如下:

Loci Name Gene Name Chromosomal Location Primer Primer # Size Range Repeat Structure Mutation Rate
D1S1656 1q42 GTGTTGCTCAAGGGTCAACT GAGAAATAGAATCACTAGGGAACC #1 121-169 [TAGA]n[TGA]n[TAGA]n[TAGG]n[TG]n
D2S441 2p14 TGCACCCAACATTCTAACAA ATTGGAGCTAAGTGGCTGTG #1 78-114 [TCTA]n
D2S1338 2q35 [TGCC]n[TTCC]n 0.12%
D10S1248 10q26.3 GGAATAAGTGCAGTGCTTGG ACCAATCTGGTCACAACCAT #1 227-271 [GGAA]n
D12S391 Chr12 AACAGGATCAATGGATGCAT TGGCTTTTAGACCTGGACTG #1 209-253 [AGAT]8-17[AGAC]6-10[AGAT]0-1
D19S433 19q12 CCTGGGCAACAGAATAAGAT TAGGTTTTTAAGGAACAGGTGG #1 [AAGG][AAAG][AAGG][TAGG][AAGG]12 0.11%
D22S1045 IL2RB 22q12.3 GCTAGATTTTCCCCGATGAT ATGTAAAGTGCTCTCAAGAGTGC #1 129-165 [ATT]n[ACT][ATT]n
  • 本文作者:括囊无誉
  • 本文链接: BIO/CODIS CORE STR LOCI概况/
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